ABSTRACT
Objective To investigate the prevalence of human papilloma virus (HPV) infections among gynecological patients and to identify the risk factors associated with high-risk HPV (HR-HPV)infection.Methods HPV DNA genotyping was performed in 391 HPV infected gynecological patients admitted in Weifang People's Hospital during January 2010 and December 2012.HPV negative patients (controls,n =356) were matched to HR-HPV positive patients (cases,n =356) with a 1 ∶ 1 ratio.All the participants took part in a questionnaire survey with 50 items,including demographic characteristics,pregnancy and reproductive history,living conditions,sexual behavior,family history,etc.Stepwise Logistic regression analysis was used to determine the risk factors of HR-HPV infection.Results Among 391 HPV positive patients,318 (81.3％) were infected with one type of HR-HPV,35 (9.0％) were infected with one type of low-risk HPV,and 38 (9.7％) were infected with mixed types.Logistic regression analysis showed that married women,age of sexual debut ＜ 20,multiple sexual partners,oral sex,commercial sexual activity,and vaginal douching more than once a week were risk factors of HR-HPV infection (OR =4.053,1.861,1.587,2.420,5.125 and 1.943,respectively,all P ＜ 0.01).Conclusions Unprotected sex may be associated with HR-HPV infection.Healthy sexual behavior should be encouraged,and the detection,prevention and control of HR-HPV infection should be strengthened.